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    Curr Opin Pediatr. 1999 Oct;11(5):447-56.

    Minocycline and autoimmunity.

    Source

    Division of Pediatric Rheumatology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.

    Abstract

    Minocycline is the most widely prescribed systemic antibiotic for the management of acne. In the past several years, increasing attention has been paid to the drug, both for its potential use as a disease-modifying antirheumatic agent and for its propensity to engender untoward autoimmune reactions, including serum sickness-like disease, drug-induced lupus, and autoimmune hepatitis. This paper reviews the evidence for minocycline as an anti-inflammatory and immunomodulatory agent, its utility in the treatment of rheumatoid arthritis, and the spectrum of adverse reactions that have been ascribed to the drug in the past 5 years.

    PMID:
    10555598
    [PubMed - indexed for MEDLINE]

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