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Radiology. 1999 Nov;213(2):352-61.

Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases.

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  • 1Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA.

Abstract

PURPOSE:

To review characteristic findings of fibrolamellar hepatocellular carcinoma (HCC) at computed tomography (CT) and magnetic resonance (MR) imaging.

MATERIALS AND METHODS:

The authors retrospectively reviewed the clinical, pathologic, and preoperative imaging findings in 31 patients with histologically proved fibrolamellar HCC. Dynamic contrast material-enhanced CT of the liver was performed in 31 patients, helical multiphase CT in 21, and MR imaging in 11. Complete resection was performed in 17 patients, and imaging-pathologic correlation was performed.

RESULTS:

Large tumors (mean diameter, 13 cm) were depicted at CT and MR in all cases. At CT, the margins of the tumors were well defined in 24 (77%) of 31 cases calcifications were depicted in 21 (68%), a central scar in 22 (71%), and abdominal lymphadenopathy in 20 (65%). In 20 (80%) of 25 cases with hepatic arterial phase CT images, all tumors were heterogeneous and depicted areas of hypervascularity. At MR imaging, tumors were hypointense to liver on T1-weighted images (n = 11) and hyperintense to liver on T2-weighted images (n = 10). Calcification was not depicted on MR images, but a central scar was depicted as hypointense to surrounding tumor in nine cases.

CONCLUSION:

CT and MR images demonstrate characteristic features that may allow confident diagnosis of fibrolamellar HCC.

PMID:
10551212
[PubMed - indexed for MEDLINE]
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