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Biol Pharm Bull. 1999 Oct;22(10):1094-8.

Renal targeting of arginine-vasopressin by modification with carbohydrates at the tyrosine side chain.

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  • 1Noda Research Laboratories, Drug Delivery System Institute, Ltd., Chiba, Japan.

Abstract

To extend the utility of a renal targeting system using carbohydrate derivatives, we investigated the in vivo tissue distribution in rats of arginine-vasopressin (AVP) derivatives modified at the phenolic hydroxy group of tyrosine by linking it to some sugars, namely D-glucose, D-galactose, D-mannose and L-fucose, via an octamethylene group. The glycosyl and mannosyl derivatives of AVP exhibit renal-selective distribution in vivo. In addition, the glucosyl and mannosyl derivatives exhibited specific binding to the kidney microsomal fraction in vitro. Modification with D-glucose or D-mannose at the tyrosine side chain is a suitable methodology for renal targeting, as well as at N-terminal amine.

PMID:
10549862
[PubMed - indexed for MEDLINE]
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