Curr Opin Hematol. 1999 Nov;6(6):400-5.

Hematopoietic stem cell transplantation for autoimmune disorders.

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Division of Hematology, Kantonsspital Basel, Switzerland. passweg@ubaclu.unibas.ch

Abstract

Autologous hemopoietic stem cell transplantation (HSCT) for autoimmune disease has increased lately. Insights into response to immunoablation is found in animal experiments and reports on patients receiving HSCT for concomitant malignancy. Early phase II studies and case reports of HSCT in patients with multiple sclerosis, systemic sclerosis, lupus erythematosus, rheumatoid arthritis, juvenile chronic arthritis and idiopathic thrombocytopenic purpura have been published. Dramatic responses or disease stabilization have been observed in some, but failures and disease relapses, toxic and infectious complications have been observed in others. Whether this treatment can induce true peripheral immunologic tolerance, and which been observed if any patients will benefit long-term from HSCT, remains to be determined.

PMID:: 10546794; [PubMed - indexed for MEDLINE]

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Review Stem cell transplantation for autoimmune diseases. [Best Pract Res Clin Haematol. ...]
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Cited by 1 PubMed Central article

Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity. [Ann Rheum Dis. 2004]
Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity.
De Kleer IM, Brinkman DM, Ferster A, Abinun M, Quartier P, Van Der Net J, Ten Cate R, Wedderburn LR, Horneff G, Oppermann J, et al. Ann Rheum Dis. 2004 Oct; 63(10):1318-26.

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