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Proc Natl Acad Sci U S A. 1975 Jan;72(1):362-6.

Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m-7G(5')ppp(5')G-MpCp-.

Abstract

Reovirus mRNA synthesized in vitro by the virus-associated RNA polymerase in the presence of S-adenosylmethionine contains blocked, methylated 5'-termini with the structure, m-7G(5')ppp(5')G-MpCp. The functional significance and possible mechanism of formation of this novel 5'-5' terminal nucleotide linkage are discussed.

PMID:
1054511
[PubMed - indexed for MEDLINE]
PMCID:
PMC432305
Free PMC Article
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