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Ophthalmic Epidemiol. 1999 Dec;6(4):247-55.

Incident cataract after a five-year interval and lifestyle factors: the Beaver Dam eye study.

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  • 1University of Wisconsin Medical School, Department of Ophthalmology & Visual Sciences, Madison, WI 53705-2397, USA.

Abstract

CONTEXT:

A population-based study to investigate risk factors for age-related eye disease was begun in 1987 in a representative American community. Incidence of cataract was subsequently evaluated.

SPECIFIC OBJECTIVES:

To examine the relationships of cigarette smoking, alcohol, and caffeine intakes to incidence of age-related cataracts five years later.

DESIGN:

Observational epidemiologic incidence study of an adult population.

PARTICIPANTS AND INTERVENTION:

Adults 43-84 years of age were identified during a census in 1987-1988, and examined at baseline (1988-1990) and after a five-year interval (1993-1995).

MAIN OUTCOME MEASURE:

Standardized protocols were used at the baseline and follow-up evaluations for exposures and for objective identification of cataracts.

RESULTS:

Cumulative incidence of nuclear cataract in right eyes was about 12%, cortical cataract about 8%, and posterior subcapsular cataract about 3%. In multivariable analyses of the general estimating equations type, there were significant associations between nuclear cataract and: pack-years smoked (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.01, 1.09 per 10 pack-years); and current alcohol intake (OR 1.01, 95% CI 1.00, 1.02 per 10 grams ethanol/week). Cigarette smokers were more likely to have had cataract surgery in the interval between baseline and follow-up examinations.

CONCLUSIONS:

Cigarette smoking and alcohol consumption were associated with modestly increased risks of incident nuclear cataract over a five-year interval.

PMID:
10544339
[PubMed - indexed for MEDLINE]
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