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    J Bacteriol. 1999 Nov;181(21):6840-3.

    Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes.

    Source

    Department of Microbiology, University College Cork, Cork, Ireland.

    Abstract

    lisRK encodes a two-component regulatory system in the food pathogen Listeria monocytogenes LO28. Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence.

    PMID:
    10542190
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC94153
    Free PMC Article

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