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    Schizophr Res. 1999 Nov 9;40(1):23-9.

    The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains.

    Davidsson P, Gottfries J, Bogdanovic N, Ekman R, Karlsson I, Gottfries CG, Blennow K.

    Institute of Clinical Neuroscience, Göteborg University, Sahlgrenska University Hospital/Mölndal, Mölndal, Sweden. pia.davidsson@ms.se

    Two synaptic-vesicle proteins, rab3a and synaptophysin, have been studied on post-mortem brain tissues of schizophrenics and healthy controls. We found significantly reduced levels of rab3a in thalamus (p<0.001); for both proteins in gyrus cinguli and hippocampus (p<0.0001); for rab3a in frontal and parietal cortex (p<0.05); and no differences in temporal cortex or cerebellum in schizophrenics compared with controls. Reduced synaptic density may be a prominent feature of the molecular neuropathology of schizophrenia.

    PMID: 10541003 [PubMed - indexed for MEDLINE]

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