Cancer Res. 1999 Oct 15;59(20):5102-5.

Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells.

Kawano T, Nakayama T, Kamada N, Kaneko Y, Harada M, Ogura N, Akutsu Y, Motohashi S, Iizasa T, Endo H, Fujisawa T, Shinkai H, Taniguchi M.

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Core Research for Evolutional Science and Technology Project and Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Japan.

Abstract

Human V alpha24 NKT cells bearing an invariant V alpha24J alphaQ antigen receptor, the counterpart of the murine V alpha14 NKT cells, are activated by the specific ligand, alpha-galactosylceramide (alpha-GalCer) in a CD1d-dependent manner. Here, we demonstrate that the alpha-GalCer-activated V alpha24 NKT cells exert a potent perforin-dependent cytotoxic activity against a wide variety of human tumor cell lines. In addition, we demonstrate that V alpha24 NKT cells and dendritic cells (DCs) from melanoma patients are functionally normal, even in the tumor-bearing status. The potential use of alpha-GalCer-activated V alpha24 NKT cells and/or DCs from patients for cancer immunotherapy is discussed.

PMID:: 10537282; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Glycolipids

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