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Neurology. 1999 Oct 22;53(7):1588-9.

Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis.

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  • 1Department of Neurological Sciences, Università La Sapienza, Rome, Italy.


We studied the effect of Bacille Calmette-Guerin (BCG) vaccine as an immunomodulator in MS. According to the guidelines for clinical trials in MS, a single crossover, MRI-monitored trial was performed in 14 patients with relapsing-remitting MS. After treatment, MRI activity was significantly reduced. No major adverse effects were reported. Adjuvant therapy with BCG vaccine was safe and merits study in MS.

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