Neurology. 1999 Oct 22;53(7):1588-9.

Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis.

Ristori G, Buzzi MG, Sabatini U, Giugni E, Bastianello S, Viselli F, Buttinelli C, Ruggieri S, Colonnese C, Pozzilli C, Salvetti M.

Source

Department of Neurological Sciences, Università La Sapienza, Rome, Italy.

Abstract

We studied the effect of Bacille Calmette-Guerin (BCG) vaccine as an immunomodulator in MS. According to the guidelines for clinical trials in MS, a single crossover, MRI-monitored trial was performed in 14 patients with relapsing-remitting MS. After treatment, MRI activity was significantly reduced. No major adverse effects were reported. Adjuvant therapy with BCG vaccine was safe and merits study in MS.

Comment in

Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis. [Neurology. 2000]
Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis.Kruisdijk JJ, Linssen WH. Neurology. 2000 Jul 12; 55(1):157.

PMID:: 10534275; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

The effect of Bacille Calmette-Guérin on the evolution of new enhancing lesions to hypointense T1 lesions in relapsing remitting MS. [J Neurol. 2003]
The effect of Bacille Calmette-Guérin on the evolution of new enhancing lesions to hypointense T1 lesions in relapsing remitting MS.
Paolillo A, Buzzi MG, Giugni E, Sabatini U, Bastianello S, Pozzilli C, Salvetti M, Ristori G. J Neurol. 2003 Feb; 250(2):247-8.
Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis. [Neurology. 2000]
Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis.
Kruisdijk JJ, Linssen WH. Neurology. 2000 Jul 12; 55(1):157.
Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group. [Neurology. 1999]
Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group.
Rudick RA, Fisher E, Lee JC, Simon J, Jacobs L. Neurology. 1999 Nov 10; 53(8):1698-704.
Review Intravesical Bacillus Calmette-Guerin in Ta and T1 Bladder Cancer. [Cochrane Database Syst Rev. 2000]
Review Intravesical Bacillus Calmette-Guerin in Ta and T1 Bladder Cancer.
Shelley MD, Court JB, Kynaston H, Wilt TJ, Fish RG, Mason M. Cochrane Database Syst Rev. 2000; (4):CD001986.
Review Mitoxantrone: a review of its use in multiple sclerosis. [CNS Drugs. 2004]
Review Mitoxantrone: a review of its use in multiple sclerosis.
Scott LJ, Figgitt DP. CNS Drugs. 2004; 18(6):379-96.

See reviews... See all...

Cited by 6 PubMed Central articles

Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. [PLoS One. 2012]
Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes.
Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, et al. PLoS One. 2012; 7(8):e41756. Epub 2012 Aug 8.
BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease. [PLoS One. 2011]
BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.
Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL. PLoS One. 2011 Jan 31; 6(1):e16610. Epub 2011 Jan 31.
Review Mycobacteria-induced suppression of autoimmunity in the central nervous system. [J Neuroimmune Pharmacol. 2010]
Review Mycobacteria-induced suppression of autoimmunity in the central nervous system.
Lee J, Sandor M, Heninger E, Fabry Z. J Neuroimmune Pharmacol. 2010 Jun; 5(2):210-9. Epub 2010 Mar 24.

See all...

Recent activity

Clear Turn Off Turn On

Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis.
Use of Bacille Calmette-Guèrin (BCG) in multiple sclerosis.
Neurology. 1999 Oct 22 ;53(7):1588-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: