Lancet. 1999 Oct 16;354(9187):1353-4.

Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine.

Abstract

Diets containing genetically modified (GM) potatoes expressing the lectin Galanthus nivalis agglutinin (GNA) had variable effects on different parts of the rat gastrointestinal tract. Some effects, such as the proliferation of the gastric mucosa, were mainly due to the expression of the GNA transgene. However, other parts of the construct or the genetic transformation (or both) could also have contributed to the overall biological effects of the GNA-GM potatoes, particularly on the small intestine and caecum.

Comment in

GM food debate. [Lancet. 1999]
GM food debate.Feldbaum CB. Lancet. 1999 Nov 13; 354(9191):1729.
GM food debate. [Lancet. 1999]
GM food debate.Klug A. Lancet. 1999 Nov 13; 354(9191):1729.
GM food debate. [Lancet. 1999]
GM food debate.FitzGerald AJ, Goodlad RA, Wright NA. Lancet. 1999 Nov 13; 354(9191):1725-6; author reply 1726-7.
GM food debate. [Lancet. 1999]
GM food debate.Kilpatrick DC. Lancet. 1999 Nov 13; 354(9191):1728; author reply 1728-9.
Rats and risk. [Lancet. 2001]
Rats and risk.Morris S, Powell D. Lancet. 2001 Jan 27; 357(9252):309-10.
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Genetically modified foods: "absurd" concern or welcome dialogue?Horton R. Lancet. 1999 Oct 16; 354(9187):1314-5.
Adequacy of methods for testing the safety of genetically modified foods. [Lancet. 1999]
Adequacy of methods for testing the safety of genetically modified foods.Kuiper HA, Noteborn HP, Peijnenburg AA. Lancet. 1999 Oct 16; 354(9187):1315-6.
GM food debate. [Lancet. 1999]
GM food debate.Mowat A. Lancet. 1999 Nov 13; 354(9191):1725; author reply 1726-7.
GM food debate. [Lancet. 1999]
GM food debate.Lachmann P. Lancet. 1999 Nov 13; 354(9191):1726; author reply 1726-7.

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