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Arch Gen Psychiatry. 1999 Oct;56(10):913-9.

Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder.

Author information

  • 1Department of Psychiatry Research, Hillside Hospital, North-Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA. szeszko@lij.edu

Abstract

BACKGROUND:

Functional neuroimaging studies have implicated the frontal lobes and the hippocampus-amygdala complex in the pathophysiology of obsessive-compulsive disorder (OCD). These brain regions have not been well investigated in patients with OCD, however, using magnetic resonance imaging.

METHODS:

Volumes of the superior frontal gyrus, anterior cingulate gyrus, orbital frontal region, hippocampus, and amygdala were computed from contiguous magnetic resonance images in a sample of 26 patients with OCD and 26 healthy comparison subjects.

RESULTS:

Patients with OCD had significantly reduced bilateral orbital frontal and amygdala volumes compared with healthy comparison subjects and lacked the normal hemispheric asymmetry of the hippocampus-amygdala complex. Neither brain structure volumes nor asymmetry indices were significantly correlated with total illness duration or length of current OCD episode.

CONCLUSIONS:

Findings of reduced orbital frontal and amygdala volumes in patients implicate a structural abnormality of these brain regions in the pathophysiology of OCD. Absence of the normal hemispheric asymmetry of the hippocampus-amygdala complex in patients is consistent with an anomalous neurodevelopmental process.

PMID:
10530633
[PubMed - indexed for MEDLINE]
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