Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Rheumatol. 1999 Oct;26(10):2148-52.

Genetic analysis of the contribution of IL10 to systemic lupus erythematosus.

Author information

  • 1Department of Genetics and Pathology, University of Uppsala, Sweden.

Abstract

OBJECTIVE:

To study the contribution of the IL10 gene to the susceptibility to systemic lupus erythematosus (SLE).

METHODS:

Analysis by fluorescent-semiautomated genotyping of a dinucleotide repeat located in the promoter region of the IL10 locus (microsatellite G).

RESULTS:

No significant difference was found in the frequencies of the microsatellite alleles of 330 Mexican patients with SLE compared to 368 controls from the same population. Two-point linkage analyses were carried out using 13 Mexican, 13 Swedish, and 8 Icelandic families with 2 or more cases with SLE. No linkage was revealed between IL10 and SLE, using a variety of parameter settings.

CONCLUSION:

Our results do not support that the IL10 gene contributes to the susceptibility to SLE in the populations we studied.

PMID:
10529131
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk