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Cephalalgia. 1999 Sep;19(7):684-91.

Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine.

Author information

  • 1San Francisco Headache Clinic, CA, USA. SFHACLIN@aol.com

Abstract

OBJECTIVE:

To examine the benefits of acetaminophen, aspirin, and caffeine (AAC) in the treatment of severe, disabling migraine attacks, in a population of migraine sufferers for whom over-the-counter (OTC) medications are appropriate.

BACKGROUND:

Subjects (n = 1220) who met the International Headache Society criteria for migraine with or without aura were included in three independent clinical studies.

DESIGN/METHODS:

Post-hoc analysis of 172 subjects who met the criteria for severe, disabling migraine reported a history of migraine attacks characterized by at least severe pain and severe disability, and treated attacks with severe pain and at least severe disability. Subjects who usually vomited with 20% or more of their migraine attacks, and those with incapacitating disability (subjects who required bed rest for more than 50% of their attacks) were not eligible for enrollment.

RESULTS:

From 1 h and continuing through 6 h postdose, the proportion of responders was significantly greater (p< or =0.01) for AAC than placebo. The pain intensity difference from baseline was significantly greater (p< or =0.05) for AAC than placebo from 0.5 h through 6 h. The proportion of subjects reporting improvement in functional disability, photophobia, and phonophobia was significantly greater for AAC than placebo from 2 h through 6 h postdose.

CONCLUSIONS:

The nonprescription combination of AAC was well tolerated and effective.

PMID:
10524663
[PubMed - indexed for MEDLINE]
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