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Neurology. 1999 Oct 12;53(6):1330-2.

Evidence for the GluR6 gene associated with younger onset age of Huntington's disease.

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  • 1Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Abstract

Huntington's disease (HD) is attributed to a triplet CAG repeat mutation, and about half of the variation in onset age can be explained by the size of the repeat expansion. Recently, a TAA repeat polymorphism in close linkage to the kainate receptor, GluR6, was reported related to onset age in HD. We examined this polymorphism in 258 unrelated HD-affected persons (172 from a clinic sample and 86 from a postmortem series). This study confirms that the 155 allele is associated with younger onset age of HD and suggests that it is in linkage disequilibrium with a variant of the GluR6 gene or another gene in this region.

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PMID:
10522893
[PubMed - indexed for MEDLINE]
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