Am J Hum Genet. 1999 Nov;65(5):1396-400.

Identification of a new locus for generalized epilepsy with febrile seizures plus (GEFS+) on chromosome 2q24-q33.

Moulard B, Guipponi M, Chaigne D, Mouthon D, Buresi C, Malafosse A.

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Division de Neuropsychiatrie, Hôpitaux Universitaires de Genève, Chêne-Bourg, Switzerland.

Abstract

We report the identification of a new locus for generalized epilepsy with febrile seizures plus (GEFS+). Six family members manifested isolated typical febrile seizures (FS), and five had typical FS associated with generalized epilepsy (FS+, generalized tonic/clonic seizures). Afebrile seizures occurred from childhood until the teenage years. The maximum two-point LOD score was 3.99 for markers D2S294 and D2S2314. Flanking markers place the GEFS+ locus between D2S141 and D2S116, with multipoint analysis favoring the 13-cM interval spanned by D2S294 and D2S364. This locus is the second GEFS+ locus to be reported, which suggests that this syndrome is genetically heterogeneous.

PMID:: 10521305; [PubMed - indexed for MEDLINE]
PMCID:: PMC1288292

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Identification of a new locus for generalized epilepsy with febrile seizures plu...
Identification of a new locus for generalized epilepsy with febrile seizures plus (GEFS+) on chromosome 2q24-q33.
Am J Hum Genet. 1999 Nov ;65(5):1396-400.

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