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1: DNA Seq. 1998;9(3):163-9.Links

Computer sequence analysis of human highly conserved zinc finger modules.

Petroni D, Bartolini E, Chiaramonte R, Ottolenghi S, Comi P.

Dept. of Biomedical Sciences and Technologies, HSR, University of Milan, Italy.

We defined a sub-family of zinc finger proteins by computer analyses and comparisons of five new finger domains against protein databases. This subclass of the cysteine-cysteine/histidine-histidine motif shows additional well conserved amino acid patterns and belongs to the human kox and gli-Kruppel gene family, sharing also the same stretches of regulatory zinc finger-containing proteins of mouse and Xenopus. We particularly describe ZF6 cDNA which contains the most interesting sequence, encoding a putative multi-domain regulatory protein.

PMID: 10520746 [PubMed - indexed for MEDLINE]