Olestra increases faecal excretion of 2,3,7,8-tetr...[Lancet. 1999]

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1: Lancet. 1999 Oct 9;354(9186):1266-7. Links

Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Geusau A, Tschachler E, Meixner M, Sandermann S, Päpke O, Wolf C, Valic E, Stingl G, McLachlan M.

Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.

PMID: 10520643 [PubMed - indexed for MEDLINE]

Severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients.
Arch Toxicol. 2002 Jun; 76(5-6):316-25. Epub 2002 May 4.

[Arch Toxicol. 2002]
Cutaneous elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
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[Br J Dermatol. 2001]
A non-absorbable dietary fat substitute enhances elimination of persistent lipophilic contaminants in humans.
Chemosphere. 1999 Oct; 39(9):1513-21.

[Chemosphere. 1999]
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[Obes Rev. 2002]
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J Toxicol Environ Health B Crit Rev. 2003 Mar-Apr; 6(2):115-59.

[J Toxicol Environ Health B Crit Rev. 2003]
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Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects.
Geusau A, Abraham K, Geissler K, Sator MO, Stingl G, Tschachler E. Environ Health Perspect. 2001 Aug; 109(8):865-9.

[Environ Health Perspect. 2001]

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Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

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