Olestra increases faecal excretion of 2,3,7,8-tetr...[Lancet. 1999]

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1: Lancet. 1999 Oct 9;354(9186):1266-7. Links

Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Geusau A, Tschachler E, Meixner M, Sandermann S, Päpke O, Wolf C, Valic E, Stingl G, McLachlan M.

Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.

PMID: 10520643 [PubMed - indexed for MEDLINE]

Severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients. [Arch Toxicol. 2002]
Cutaneous elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin. [Br J Dermatol. 2001]
A non-absorbable dietary fat substitute enhances elimination of persistent lipophilic contaminants in humans. [Chemosphere. 1999]
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects. [Environ Health Perspect. 2001]
Metabolism and disposition of 1,4,7,8-tetrachlorodibenzo-p-dioxin in rats. [Chemosphere. 1998]
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Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

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