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    J Virol. 1999 Nov;73(11):9604-8.

    Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.

    Nishizawa T, Okamoto H, Tsuda F, Aikawa T, Sugai Y, Konishi K, Akahane Y, Ukita M, Tanaka T, Miyakawa Y, Mayumi M.

    Immunology Division, Jichi Medical School, Tochigi-Ken 329-0498, Tokyo 107-0062, Japan.

    Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

    PMID: 10516070 [PubMed - indexed for MEDLINE]

    PMCID: 112996

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