Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genomics. 1999 Oct 1;61(1):15-23.

An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells.

Author information

  • 1Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.

Abstract

An olfactory receptor gene was identified near the 3' breakpoint of a naturally occurring deletion (HPFH-1) in the human beta-globin gene cluster on chromosome 11p15.5. The gene encodes an amino acid sequence that is 40 to 51% identical to that of a set of olfactory receptors that have only recently been identified as a distinct family of receptors. There are two orthologous genes in the mouse that encode amino acid sequences that are 73 and 71% identical, respectively, to that encoded by the human gene. This olfactory receptor gene is expressed at the RNA level in human and murine erythroid cells at all stages of development. This aberrant expression is probably due to the location of the gene in the transcriptionally active chromatin domain of the extended beta-globin gene cluster in erythroid cells.

Copyright 1999 Academic Press.

PMID:
10512676
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk