Display Settings:

Format

Send to:

Choose Destination
Trends Cell Biol. 1999 Nov;9(11):454-9.

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

Author information

  • 1SUGEN, 230 East Grand Avenue, South San Francisco, CA 94080-4811, USA. jim-bischoff@sugen.com

Abstract

Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can lead to aneuploidy and the propagation of genetic abnormalities. This review discusses the Aurora/Ipl1p kinases in terms of their protein structure and proposed function in mitotic cells and also the potential role of aurora2 in human cancer.

PMID:
10511710
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk