Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants

T Kunnari; K Ylihonko; A Hautala; K D Klika; P Mäntsälä; J Hakala

doi:10.1016/s0960-894x(99)00439-4

Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2639-42. doi: 10.1016/s0960-894x(99)00439-4.

Authors

T Kunnari¹, K Ylihonko, A Hautala, K D Klika, P Mäntsälä, J Hakala

Affiliation

¹ Galilaeus Oy, Kaarina, Finland. tero.kunnari@galilaeus.fi

PMID: 10509907
DOI: 10.1016/s0960-894x(99)00439-4

Abstract

Compounds produced by the polyketide ketoreductase deficient Streptomyces mutants HO61 and P67 are described. The structures of the compounds indicate that ketoreductase activity is required for correct condensation of the polyketide chain in the biosynthesis of aromatic polyketides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohol Oxidoreductases / genetics*
Bacterial Proteins*
Ethers, Cyclic / chemistry
Ethers, Cyclic / metabolism*
Molecular Structure
Mutagenesis
Streptomyces / enzymology
Streptomyces / genetics
Streptomyces / metabolism*

Substances

Bacterial Proteins
Ethers, Cyclic
Alcohol Oxidoreductases
polyketide synthase ketoreductase