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Curr Opin Neurobiol. 1999 Oct;9(5):517-24.

Lineages and transcription factors in the specification of vertebrate primary sensory neurons.

Author information

  • 1Howard Hughes Medical Institute Division of Biology 216-76 California Institute of Technology Pasadena, California 91125, USA. barres@stanford.edu

Abstract

Recent advances have indentified some of the key transcriptional regulators of mammalian genes, the neurogenins. Neurogenins 1 and 2 appear to control distinct sublineages for different classes of sensory neurons, including a 'pioneer' lineage for proprioceptors specified early in neural crest migration. Neurogenins act via a cascade of downstream transcriptional regulators, some of which have been identified.

PMID:
10508743
[PubMed - indexed for MEDLINE]

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