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Curr Opin Cell Biol. 1999 Oct;11(5):554-60.

Cadherins and their connections: adhesion junctions have broader functions.

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  • 1Department of Molecular Biology Princeton University Princeton, NJ 08544, USA. msteinberg@princeton.edu.

Abstract

Cadherins - a family of cell-cell adhesion molecules - are linked to the actin cytoskeleton via intervening proteins. Recent results address molecular explanations for observed cadherin behavior, point to signals that regulate adhesion by modulating elements of the cadherin-associated complex, challenge the belief that different cadherins generally cannot cross-adhere, and highlight instructive roles for cadherins in cell signaling and differentiation.

PMID:
10508659
[PubMed - indexed for MEDLINE]
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