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Curr Opin Biotechnol. 1999 Oct;10(5):470-6.

Engineering the mouse genome by site-specific recombination.

Author information

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP Collége de France BP 163, 67404, Illkirch Cedex, CU de Strasbourg, France. metzger@igbmc.u-strasbg.fr


Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.

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