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Cancer Lett. 1999 Sep 20;144(1):9-16.

Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability.

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  • 1Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan.

Abstract

The extent to which microsatellite instability (MI) contributes to the etiology of breast cancer has not been established in any large-scale studies. We examined 528 samples of tumor DNA from patients with primary breast cancer for MI, using 14 polymorphic CA-repeat markers. The frequency of MI in these tumors was unexpectedly low (10/528, 1.9%). The ten MI+ tumors were analyzed for mutations in five potential target genes that contain simple repeat sequences (TGFBIIR, IGF2R, hMSH6, BAX and PTEN/MMAC1). A somatic insertion of an extra adenine in the (A)6 region at codon 321-323 (exon 8) of the PTEN/MMAC1 gene, leading to a frame-shift, was identified in one tumor. This observation represented the first documented instance of PTEN/MMAC1 alteration in a MI+ primary breast cancer.

PMID:
10503872
[PubMed - indexed for MEDLINE]
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