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Trends Biochem Sci. 1999 Oct;24(10):385-9.

RMPs: recombination/replication mediator proteins.

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  • 1Dept of Biochemistry and Center for X-ray Crystallography, The University of Vermont College of Medicine, Burlington, VT 05405-0068, USA.


Enzymes for DNA replication and recombination need to gain access to single-stranded DNA (ssDNA) but ssDNA-binding proteins (SSBs) present an obstacle to the formation of enzyme-ssDNA replication and recombination complexes. A specialized class of SSBs, which we designate as recombination/replication mediator proteins (RMPs), promotes enzyme- ssDNA assembly by overcoming SSB inhibition. RMPs exhibit strong conservation of function across divergent species, and display species-specific interactions with SSB and enzymes to neutralize the SSB barrier to enzyme-ssDNA assembly.

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