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Genes Dev. 1999 Sep 15;13(18):2369-74.

Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators.

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  • 1Molecular and Cellular Biology Program, University of Washington, The Fred Hutchinson Cancer Research Center, Seattle Washington 98109 USA.


SWI/SNF is a chromatin remodeling complex that facilitates expression of a number of yeast genes. Here we demonstrate that SWI/SNF can be recruited from yeast nuclear extracts by a transcriptional activator. Recruitment is dependent on an activation domain but not on promoter sequences, TBP, or RNA polymerase II holoenzyme. We also show that acidic activation domains can target SWI/SNF remodeling activity. These results demonstrate that SWI/SNF activity can be targeted by gene-specific activators and that this recruitment can occur independently of Pol II holoenzyme.

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