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FEMS Microbiol Lett. 1999 Sep 15;178(2):313-7.

Quantitative analysis of the effect of xylitol on pneumococcal nasal colonisation in rats.

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  • 1Department of Paediatrics, University of Oulu, Finland.


Xylitol possesses anti-bacterial effects on pneumococci in vitro. To study the effect in vivo, the nostrils of 80 rats were inoculated with pneumococci. Intervention groups (n = 20) received either a xylitol diet or xylitol nasal sprays. The control groups were on a normal diet or had saline sprays. After 3 days, a quantitative bacterial culture and a PCR were done from the mucosal suspension. Neither the mean colony-forming unit counts nor the PCR counts differed statistically significant between the xylitol and control groups. Thus, we found that xylitol had no significant effect on pneumococcal mucosal colonisation.

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