Reversible pancreatitis, hepatitis, and peripheral polyneuropathy associated with parenteral gold therapy

H Ben-Ami; S Pollack; P Nagachandran; I Lashevsky; D Yarnitsky; Y Edoute

Reversible pancreatitis, hepatitis, and peripheral polyneuropathy associated with parenteral gold therapy

J Rheumatol. 1999 Sep;26(9):2049-50.

Authors

H Ben-Ami¹, S Pollack, P Nagachandran, I Lashevsky, D Yarnitsky, Y Edoute

Affiliation

¹ Department of Internal Medicine C, Rambam Medical Center, Haifa, Israel. mdhaim@tx.technion.ac.il

PMID: 10493691

Abstract

A 63-year-old man with seronegative rheumatoid arthritis developed acute pancreatitis, severe hepatitis, and sensorimotor polyneuropathy after receiving 150 mg of intramuscular aurothioglucose (gold). Positive lymphocyte transformation test to gold indicated a cell mediated hypersensitivity to the drug, while multiple investigations ruled out other underlying causes for his illness. After cessation of gold therapy a complete recovery occurred.

Publication types

Case Reports

MeSH terms

Acute Disease
Arthritis, Rheumatoid / diagnosis
Arthritis, Rheumatoid / drug therapy*
Chemical and Drug Induced Liver Injury / diagnosis
Chemical and Drug Induced Liver Injury / etiology*
Drug Hypersensitivity / diagnosis
Drug Hypersensitivity / etiology*
Gold Compounds / administration & dosage
Gold Compounds / adverse effects*
Humans
Injections, Intramuscular
Male
Middle Aged
Pancreatitis / chemically induced*
Pancreatitis / diagnosis
Peripheral Nervous System Diseases / chemically induced*
Peripheral Nervous System Diseases / diagnosis
Remission, Spontaneous

Substances

Gold Compounds