Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
JAMA. 1999 Sep 15;282(11):1073-5.

Long-term beta-carotene supplementation and risk of type 2 diabetes mellitus: a randomized controlled trial.

Author information

  • 1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. simin.liu@channing.harvard.edu

Abstract

CONTEXT:

Recent data suggest a protective role of carotenoids in the development of type 2 diabetes mellitus (DM), possibly via an antioxidant effect, but no randomized trial has directly assessed the efficacy of beta-carotene to prevent DM.

OBJECTIVE:

To determine whether long-term beta-carotene supplementation reduces the risk of developing type 2 DM.

DESIGN, SETTING, AND PARTICIPANTS:

A total of 22, 071 healthy US male physicians aged 40 to 84 years in a randomized, double- blind, placebo-controlled trial, from 1982 to 1995. More than 99% of the participants had complete follow-up (median duration, 12 years).

INTERVENTION:

Subjects were randomly assigned to receive beta-carotene (50 mg on alternate days) or placebo.

MAIN OUTCOME MEASURE:

Incidence of type 2 DM.

RESULTS:

A total of 10, 756 subjects were assigned to beta-carotene and 10, 712 to placebo. Incidence of type 2 DM did not differ between groups: 396 men in the beta-carotene group and 402 men in the placebo group developed type 2 DM (relative risk, 0.98; 95% confidence interval, 0.85-1.12). The lack of association between beta-carotene supplementation and incidence of type 2 DM persisted despite multivariate adjustment. There was no evidence of benefit when the period of risk was subdivided into years of follow-up or increasing duration of treatment.

CONCLUSION:

In this trial of apparently healthy men, supplementation with beta-carotene for an average of 12 years had no effect on the risk of subsequent type 2 DM.

PMID:
10493207
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk