Immunol Res. 1999;19(2-3):245-57.

Autoreactive T cells in murine lupus: origins and roles in autoantibody production.

Craft J, Peng S, Fujii T, Okada M, Fatenejad S.

Source

Department of Medicine, Yale University School of Medicine, New Haven, CT 06520-8031, USA. joseph.craft@yale.edu

Abstract

The conventional paradigm to explain systemic lupus erythematosus (SLE) is that disease results from tissue deposition of pathogenic autoantibodies and immune complexes, secondary to activation of autoreactive B cells in the context of help from alphabeta T cells. Recent work in murine lupus has confirmed this notion and demonstrated that autoantigen-specific alphabeta T cells are absolutely required for full penetrance of disease, with such autoreactive alphabeta T cells, even in Fas-intact mice, likely arising from defects in peripheral tolerance. These studies have also revealed a network of regulation that also involves nonclassical pathogenic and downregulatory alphabeta and gammadelta T cells, suggesting that the lupus immune system involves more complex interactions than the conventional paradigm suggests.

PMID:: 10493178; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Autoantibodies

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Lupus - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cells. [Curr Opin Rheumatol. 2005]
Review New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cells.
Bagavant H, Fu SM. Curr Opin Rheumatol. 2005 Sep; 17(5):523-8.
Propagation and regulation of systemic autoimmunity by gammadelta T cells. [J Immunol. 1996]
Propagation and regulation of systemic autoimmunity by gammadelta T cells.
Peng SL, Madaio MP, Hayday AC, Craft J. J Immunol. 1996 Dec 15; 157(12):5689-98.
T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus. [Immunology. 2000]
T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus.
Wither J, Vukusic B. Immunology. 2000 Mar; 99(3):345-51.
Regulation of T cell-dependent autoantibody production by a gammadelta T cell line derived from lupus-prone mice. [Cell Immunol. 2002]
Regulation of T cell-dependent autoantibody production by a gammadelta T cell line derived from lupus-prone mice.
Fujii T, Okada M, Craft J. Cell Immunol. 2002 May-Jun; 217(1-2):23-35.
Review Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future. [Autoimmunity. 2010]
Review Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future.
Jacob N, Stohl W. Autoimmunity. 2010 Feb; 43(1):84-97.

See reviews... See all...

Cited by 5 PubMed Central articles

The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells. [PLoS One. 2009]
The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells.
Page N, Schall N, Strub JM, Quinternet M, Chaloin O, Décossas M, Cung MT, Van Dorsselaer A, Briand JP, Muller S. PLoS One. 2009; 4(4):e5273. Epub 2009 Apr 23.
Defective B-cell response to T-dependent immunization in lupus-prone mice. [Eur J Immunol. 2008]
Defective B-cell response to T-dependent immunization in lupus-prone mice.
Niu H, Sobel ES, Morel L. Eur J Immunol. 2008 Nov; 38(11):3028-40.
T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. [J Clin Invest. 2005]
T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells.
Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, Mohan C. J Clin Invest. 2005 Jul; 115(7):1869-78. Epub 2005 Jun 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Autoreactive T cells in murine lupus: origins and roles in autoantibody producti...
Autoreactive T cells in murine lupus: origins and roles in autoantibody production.
Immunol Res. 1999 ;19(2-3):245-57.

PubMed
Dobutamine in severe scorpion envenomation: effects on standard hemodynamics, ri...
Dobutamine in severe scorpion envenomation: effects on standard hemodynamics, right ventricular performance, and tissue oxygenation.
Chest. 1999 Sep ;116(3):748-53.

PubMed
Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, an...
Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, and calretinin in the neocortex of mammals: phylogenetic and developmental patterns.
J Chem Neuroanat. 1999 Feb ;16(2):77-116.

PubMed
The effect of ankle bracing on athletic performance.
The effect of ankle bracing on athletic performance.
Sports Med. 1999 Mar ;27(3):171-8.

PubMed
Mobilising business through "partnerships for health promotion". New challenges ...
Mobilising business through "partnerships for health promotion". New challenges and new opportunities.
Promot Educ. 1999 Mar ;6(1):21-4, 37.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: