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Science. 1999 Sep 17;285(5435):1870-4.

Long-term potentiation--a decade of progress?

Author information

  • 1Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA. malenka@stanford.edu

Abstract

Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.

PMID:
10489359
[PubMed - indexed for MEDLINE]
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