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Nihon Hinyokika Gakkai Zasshi. 1999 Aug;90(8):697-705.

[Evaluation of serum D-arabinitol as a diagnostic test for invasive candidiasis in the urinary tract].

[Article in Japanese]

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  • 1Department of Urology, Tokai University School of Medicine.

Abstract

PURPOSES:

Serum D-arabinitol were measured 1) differentiate between invasive candidasis and colonization in the urinary tract 2) evaluate its efficacy for early diagnosis and treatment monitor of invasive candidasis.

MATERIALS AND METHODS:

1. Laboratory study: Serum D-arabinitol levels were measured in both candida infected rats and control rats. The cut-off levels were determined by the comparison of the two groups. Serum levels of D-arabinitol and CAND-TEC were measured every day per after candida was inoculated. Furthermore, the candida infected rats were treated with fluconazole (0.5 mg/body), and the changes of serum levels of D-arabinitol and CAND-TEC were observed. 2. Clinical study: Serum D-arabinitol, CAND-TEC and beta-D-glucan were measured to evaluate its efficacy for early diagnosis in the group with candida positive urine cultures.

RESULTS:

The cut-off levels of D-arabinitol were set 2.0 micrograms/ml, at which sensitivity was high, and specificity acceptable. The serum level of D-arabinitol raised as candida infection was established and lowered after treatment was started. CAND-TEC was negative in all materials. High levels of D-arabinitol and beta-D-glucan was measured in invasive candidasis, and lowered++ by fluconazole treatment. CAND-TEC had a low positive rate.

CONCLUSION:

Serum D-arabinitol level was sensitive for the early diagnosis of invasive candidasis and its efficacy as a monitor for treatment effects was implied.

PMID:
10487045
[PubMed - indexed for MEDLINE]
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