Trisomy 21 as the sole abnormality in a refractory anemia with ring sideroblasts

Cancer Genet Cytogenet. 1999 Sep;113(2):180-2. doi: 10.1016/s0165-4608(99)00027-8.

Abstract

Numerous chromosome abnormalities have been described in myelodysplastic syndromes, but single karyotypic aberrations are much less frequent. We report the case of a 65-year-old woman who presented a trisomy 21 as the sole karyotypic anomaly for a refractory anemia with ring sideroblasts. The nature of such an anomaly is discussed in regard to pathogenesis and prognosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anemia, Sideroblastic / genetics*
  • Bone Marrow / pathology
  • Bone Marrow / physiology
  • Down Syndrome*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence