Stimulation of human B lymphocytes by Listeria cell wall fraction

Clin Exp Immunol. 1978 Nov;34(2):193-8.

Abstract

Cell wall fraction of Listeria monocytogenes (LCWF), a B cell mitogen for mouse spleen cells, is also mitogenic for human adult and cord peripheral blood lymphocytes. Purified B-cell suspensions responded to LCWF in vitro proliferation, to a similar extent as the unfractionated suspensions. Furthermore, LCWF-induced B cell differentiation into IgM-containing cells and their percentage correlated significantly with the extent of lymphocyte proliferation.

MeSH terms

  • Adult
  • B-Lymphocytes / immunology
  • Cell Wall / immunology
  • Dose-Response Relationship, Immunologic
  • Female
  • Fetal Blood / immunology
  • Humans
  • Immunoglobulin M / analysis
  • Listeria monocytogenes / immunology*
  • Lymphocyte Activation*
  • Male
  • Periodontal Diseases / immunology
  • Pokeweed Mitogens / pharmacology
  • Subcellular Fractions / immunology
  • T-Lymphocytes / immunology

Substances

  • Immunoglobulin M
  • Pokeweed Mitogens