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    Hum Genet. 1999 Jul-Aug;105(1-2):171-3.

    A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16.

    Thomson SA, Rasmussen SA, Zhang J, Wallace MR.

    Department of Pediatrics, Center for Mammalian Genetics, University of Florida College of Medicine, Gainesville, USA.

    Hereditary cylindromatosis (HC; MIM 132700) is an autosomal dominant condition characterized by benign skin appendage tumors most commonly on the scalp and face. Previously, the HC gene (CYLD1) was linked to chromosome 16q12-13, and tumors showed loss of heterozygosity (LOH), suggesting that CYLD1 is a tumor suppressor gene. Here we report a new multi-generation cylindromatosis family whose condition maps to that region, with 7/13 tumors showing LOH on 16q.

    PMID: 10480375 [PubMed - indexed for MEDLINE]

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