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J Chromatogr A. 1999 Aug 6;852(1):305-12.

Introduction of the gene amplification technique to decrease the risk of hepatitis C virus transmission by plasma products.

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  • 1Institute of Immunology, Zagreb, Croatia.


The viral safety of plasma-derived products with respect to hepatitis C virus (HCV) is assured by selection of donors, screening of individual donations for antibodies to HCV and the incorporation of effective viral inactivation-removal steps into manufacturing processes. As antibody screening of single donations is not sufficient to completely eliminate HCV RNA positive plasmas from plasma pools, testing for HCV RNA by gene amplification techniques may be necessary to identify positive donations. Using modern molecular biology techniques, we developed a specific, sensitive and reproducible method for routine PCR screening for HCV RNA in plasma pools.

[PubMed - indexed for MEDLINE]
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