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Bioorg Med Chem Lett. 1999 Aug 16;9(16):2353-8.

Structure-based design and synthesis of a novel class of Src SH2 inhibitors.

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  • 1ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts 02139-4234, USA.


The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.

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