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Orthop Clin North Am. 1999 Oct;30(4):615-23.

Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone.

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  • 1Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.


Calcium sulfate and calcium phosphate have provided the orthopedic surgeon a viable alternative to autogenous bone grafting as either an osteoconductive bone void filler or a bone graft extender. These materials mimic the mineral phase of bone and are resorbed at a rate similar to the rate of bone formation. Thus, they are able to provide some structural support and prevent ingrowth of fibrous tissue while facilitating creeping substitution by the host bone.

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