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Acta Obstet Gynecol Scand. 1999 Sep;78(8):693-7.

Moderate smoking during pregnancy is associated with a reduced risk of preeclampsia.

Author information

  • 1Department of Obstetrics and Gynecology, University of Lund, University Hospital of Malmö, Sweden.

Abstract

BACKGROUND:

To investigate the effects of maternal smoking during pregnancy on the development of preeclampsia (PE).

METHODS:

The study comprised two populations with singleton pregnancies, one collected from 1990 to 1994 at the Malmö University Hospital (Malmö series, n=14,510) and the other from the National Birth Registry of Sweden 1993 (National series, n=113,211). Women with PE (n=281 and n=2,865, respectively) were compared to those without PE, delivered in 1993 (n=2,811 and n=110,346, respectively). The subgroups of women who had PE associated with preterm birth (n=58 and n=693, respectively) were compared with the same control groups in both series.

RESULTS:

Multiple logistic regression analysis showed that, in comparison with non-smokers, moderate smokers (1-9 cigarettes per day) were characterized by a lower incidence of PE (odds ratio (OR) 0.4; 95% confidence interval (CI) 0.22-0.60), and PE associated with preterm birth (OR 0.1; 95% CI 0.01-0.67). The corresponding figures in the validating National series were also significantly lower for moderate smokers (OR 0.6; 95% CI 0.5-0.7 and OR 0.6; 95% CI 0.5-0.8, respectively).

CONCLUSION:

Moderate smoking during pregnancy seems to protect against the development of PE and PE associated with preterm birth. Nicotine might be the agent responsible for this protective effect.

PMID:
10468061
[PubMed - indexed for MEDLINE]
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