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Biol Psychiatry. 1999 Aug 15;46(4):581-4.

Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.

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  • 1University Department of Psychiatry, Warneford Hospital, Oxford, UK.

Abstract

BACKGROUND:

We studied the effect of a single dose of a formulation of a methanolic extract of Hypericum perforatum (HP), also known as St. John's wort, on plasma concentrations of growth hormone (GH), prolactin (PRL), and cortisol (CORT) in 12 healthy male volunteers.

METHODS:

Subjects received 9 tablets of the finished product Jarsin 300 and placebo in a double-blind, balanced-order, cross-over design.

RESULTS:

Following HP relative to placebo, there was a significant increase in plasma GH and a significant decrease in plasma PRL. Plasma CORT levels were unchanged.

CONCLUSIONS:

Taken together with data from animal experimental studies, the findings suggest that this dose of HP may increase some aspects of brain dopamine function in humans.

PMID:
10459411
[PubMed - indexed for MEDLINE]
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