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Curr Opin Microbiol. 1999 Aug;2(4):438-43.

Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses.

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  • 1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.


Leishmania parasites are able to delay the onset of cell-mediated immunity by selectively impairing the ability of infected macrophages to produce interleukin (IL)-12. Leishmania infection arrests the JAK/STAT-mediated signal transduction involved in activation of the IL-12 p40 promoter; the phosphorylation defects may be initiated by ligation of the phagocyte receptors used by these organisms to gain entry into the host cell.

[PubMed - indexed for MEDLINE]
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