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Immunol Cell Biol. 1999 Aug;77(4):289-303.

Interactions of HIV-1 with antigen-presenting cells.

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  • 1Department of Pathology, University of Edinburgh Medical School, Edinburgh, United Kingdom. t.j.hewson@ed.ac.uk


There is currently much interest in the numerical and functional loss of antigen-presenting cells (APC) in HIV-1 disease and the contribution that this may make to HIV-1 pathology. The HIV-1 virus can interfere with the normal function of APC in a number of ways involving inappropriate signalling. These include changes in cytokine balance, cell-surface molecule expression and intracellular signalling pathways. This review examines how HIV-1 is able to disregulate APC function and discusses possible outcomes for the function of the immune system.

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