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Infect Immun. 1999 Sep;67(9):4935-8.

Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination.

Author information

  • 1Department of Internal Medicine and Center for Vaccine Development, Saint Louis University, St. Louis, Missouri, USA. lottenkr@slu.edu

Abstract

Immunoglobulin G (IgG) subclass antibody responses to pneumococcal vaccines were determined for human subjects in four age groups. The ratios of IgG1/IgG2 antibody concentrations declined with advancing age for all five of the serotypes tested. Protein-conjugate vaccines elicited enhanced IgG antibody responses over plain polysaccharide vaccines in infants but not in adult groups.

PMID:
10456954
PMCID:
PMC96832
[PubMed - indexed for MEDLINE]
Free PMC Article
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