FEBS Lett. 1999 Aug 6;456(2):243-8.

Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles.

Pestov NB, Adams G, Shakhparonov MI, Modyanov NN.

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Department of Pharmacology, Medical College of Ohio, Toledo 43614, USA.

Abstract

We have identified the fifth member of the mammalian X,K-ATPase beta-subunit gene family. The human and rat genes are largely expressed in skeletal muscle and at a lower level in heart. The deduced human and rat proteins designated as beta(muscle) (beta(m)) consist of 357 and 356 amino acid residues, respectively, and exhibit 89% identity. The sequence homology of beta(m) proteins with known Na,K- and H,K-ATPase beta-subunits are 30.5-39.4%. Unlike other beta-subunits, putative beta(m) proteins have large N-terminal cytoplasmic domains containing long Glu-rich sequences. The data obtained indicate the existence of hitherto unknown X,K-ATPase (most probably Na,K-ATPase) isozymes in muscle cells.

PMID:: 10456317; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

Na(+), K(+)-ATPase Subunit Composition in a Human Chondrocyte Cell Line; Evidence for the Presence of α1, α3, β1, β2 and β3 Isoforms. [Int J Mol Sci. 2012]
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FEBS Lett. 1999 Aug 6 ;456(2):243-8.

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