Your browser version may not work well with NCBI's Web applications. More information here...
1: Heart. 1999 Sep;82(3):383-5.Click here to read Click here to read Links

Effect of an alpha(2) agonist (mivazerol) on limiting myocardial ischaemia in stable angina.

Fox K, Dargie HJ, de Bono DP, Oliver MF, Wülfert E, Kharkevitch T.

Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, UK.

A specific alpha(2) agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.

PMID: 10455094 [PubMed - indexed for MEDLINE]

PMCID: PMC1729187