Cytogenet Cell Genet. 1999;85(3-4):221-6.

Mapping and complex expression pattern of the human NPAP60L nucleoporin gene.

Trichet V, Shkolny D, Dunham I, Beare D, McDermid HE.

Source

Department of Biological Sciences, University of Alberta, Edmonton, Canada.

Abstract

From a clone mapping to human chromosome 22q13.3, we have identified NPAP60L, the human homolog of the rat nuclear pore-associated protein gene, Npap60. The expression pattern of the human copy is much more complex that that of the rat, although conservation of the potential specific function of NPAP60L in male germ cells can be seen for one of the five transcripts. The exon-intron organization of the NPAP60L gene shows the presence of at least three alternate 3' ends, and Northern analysis indicates the possible presence of alternate 5' ends. Somatic cell hybrid mapping revealed additional related copies of NPAP60L on human chromosomes 5, 6, and 14, although it is not known if these are functional genes.

PMID:: 10449902; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Research Materials

anti-Nucleoporin 50kDa (NUP50) antibody - antibodies-online

Supplemental Content

Icon for S. Karger AG, Basel, Switzerland

Save items

Related citations in PubMed

Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. [Gene. 2003]
Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs.
Suh YH, Shin YK, Kook MC, Oh KI, Park WS, Kim SH, Lee IS, Park HJ, Huh TL, Park SH. Gene. 2003 Mar 27; 307:63-76.
A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. [Hum Genet. 1999]
A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.
Chen H, Rossier C, Morris MA, Scott HS, Gos A, Bairoch A, Antonarakis SE. Hum Genet. 1999 Nov; 105(5):399-409.
The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. [Genomics. 1993]
The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23.
Danielson KG, Fazzio A, Cohen I, Cannizzaro LA, Eichstetter I, Iozzo RV. Genomics. 1993 Jan; 15(1):146-60.
cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. [Genomics. 1997]
cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation.
Fan F, Liu CP, Korobova O, Heyting C, Offenberg HH, Trump G, Arnheim N. Genomics. 1997 Mar 15; 40(3):444-53.
Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene. [Gene. 1998]
Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene.
Nakano M, Yoshiura K, Oikawa M, Miyoshi O, Yamada K, Kondo S, Miwa N, Soeda E, Jinno Y, Fujii T, et al. Gene. 1998 Dec 28; 225(1-2):59-65.

See reviews... See all...

Cited by 4 PubMed Central articles

Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import. [Mol Biol Cell. 2010]
Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import.
Ogawa Y, Miyamoto Y, Asally M, Oka M, Yasuda Y, Yoneda Y. Mol Biol Cell. 2010 Feb 15; 21(4):630-8. Epub 2009 Dec 16.
Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex. [Mol Cell Biol. 2000]
Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex.
Smitherman M, Lee K, Swanger J, Kapur R, Clurman BE. Mol Cell Biol. 2000 Aug; 20(15):5631-42.
Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. [Mol Cell Biol. 2000]
Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export.
Guan T, Kehlenbach RH, Schirmer EC, Kehlenbach A, Fan F, Clurman BE, Arnheim N, Gerace L. Mol Cell Biol. 2000 Aug; 20(15):5619-30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mapping and complex expression pattern of the human NPAP60L nucleoporin gene.
Mapping and complex expression pattern of the human NPAP60L nucleoporin gene.
Cytogenet Cell Genet. 1999 ;85(3-4):221-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Mapping and complex expression pattern of the human NPAP60L nucleoporin gene.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support

Publication Types

MeSH Terms

Substances

Secondary Source ID

Grant Support

LinkOut - more resources

Full Text Sources

Research Materials

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information