Neurology. 1999 Aug 11;53(3):448-56.

The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis.

Fazekas F, Barkhof F, Filippi M, Grossman RI, Li DK, McDonald WI, McFarland HF, Paty DW, Simon JH, Wolinsky JS, Miller DH.

Source

Department of Neurology and MRI Center, Karl-Franzens University, Graz, Austria. franz.fazekas@kfunigraz.ac.at

Abstract

MRI is very sensitive in showing MS lesions throughout the CNS. Using MRI for diagnostic purposes, however useful, is a complex issue because of limited specificity of findings and a variety of options as to when, how, and which patients to examine. Comparability of data and a common view regarding the impact of MRI are needed. Following a review of the typical appearance and pattern of MS lesions including differential diagnostic considerations, we suggest economic MRI examination protocols for the brain and spine. Recommendations for referral to MRI consider the need to avoid misdiagnosis and the probability of detecting findings of diagnostic relevance. We also suggest MRI classes of evidence for MS to determine the diagnostic weight of findings and their incorporation into the clinical evaluation. These proposals should help to optimize and standardize the use of MRI in the diagnosis of MS.

PMID:: 10449103; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

491/Multiple Sclerosis Society/United Kingdom

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review The role of MRI in the diagnosis of multiple sclerosis. [Adv Neurol. 2006]
Review The role of MRI in the diagnosis of multiple sclerosis.
Traboulsee AL, Li DK. Adv Neurol. 2006; 98:125-46.
The accuracy of magnetic resonance imaging in patients with suspected multiple sclerosis. The Rochester-Toronto Magnetic Resonance Imaging Study Group. [JAMA. 1993]
The accuracy of magnetic resonance imaging in patients with suspected multiple sclerosis. The Rochester-Toronto Magnetic Resonance Imaging Study Group.
Mushlin AI, Detsky AS, Phelps CE, O'Connor PW, Kido DK, Kucharczyk W, Giang DW, Mooney C, Tansey CM, Hall WJ. JAMA. 1993 Jun 23-30; 269(24):3146-51.
[Recommendations for using and interpreting magnetic resonance imaging in multiple sclerosis]. [Neurologia. 2010]
[Recommendations for using and interpreting magnetic resonance imaging in multiple sclerosis].
Rovira A, Tintoré M, Alvarez-Cermeño JC, Izquierdo G, Prieto JM. Neurologia. 2010 May; 25(4):248-65.
Review [Magnetic resonance imaging in multiple sclerosis]. [Pathol Biol (Paris). 2000]
Review [Magnetic resonance imaging in multiple sclerosis].
Tourbah A, Berry I. Pathol Biol (Paris). 2000 Mar; 48(2):151-61.
Review Unenhanced and enhanced magnetic resonance imaging in the diagnosis of multiple sclerosis. [J Neurol Neurosurg Psychiatry....]
Review Unenhanced and enhanced magnetic resonance imaging in the diagnosis of multiple sclerosis.
Fazekas F, Barkhof F, Filippi M. J Neurol Neurosurg Psychiatry. 1998 May; 64 Suppl 1:S2-5.

See reviews... See all...

Cited by 8 PubMed Central articles

Clone clusters in autoreactive CD4 T-cell lines from probable multiple sclerosis patients form disease-characteristic signatures. [Immunology. 2009]
Clone clusters in autoreactive CD4 T-cell lines from probable multiple sclerosis patients form disease-characteristic signatures.
Mandel M, Achiron A, Tuller T, Barliya T, Rechavi G, Amariglio N, Loewenthal R, Lavie G. Immunology. 2009 Oct; 128(2):287-300.
Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis. [Brain. 2008]
Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis.
Lucchinetti CF, Gavrilova RH, Metz I, Parisi JE, Scheithauer BW, Weigand S, Thomsen K, Mandrekar J, Altintas A, Erickson BJ, et al. Brain. 2008 Jul; 131(Pt 7):1759-75. Epub 2008 Jun 5.
Identification of molecular biomarkers for multiple sclerosis. [J Mol Diagn. 2007]
Identification of molecular biomarkers for multiple sclerosis.
Fossey SC, Vnencak-Jones CL, Olsen NJ, Sriram S, Garrison G, Deng X, Crooke PS 3rd, Aune TM. J Mol Diagn. 2007 Apr; 9(2):197-204.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The contribution of magnetic resonance imaging to the diagnosis of multiple scle...
The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis.
Neurology. 1999 Aug 11 ;53(3):448-56.

PubMed
Performance and muscle fiber adaptations to creatine supplementation and heavy r...
Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training.
Med Sci Sports Exerc. 1999 Aug ;31(8):1147-56.

PubMed
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association wi...
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.
Nature. 1999 Aug 5 ;400(6744):581-5.

PubMed
Psychosocial correlates of dietary intake: advancing dietary intervention.
Psychosocial correlates of dietary intake: advancing dietary intervention.
Annu Rev Nutr. 1999 ;19:17-40.

PubMed
Haematospermia associated with malignant hypertension.
Haematospermia associated with malignant hypertension.
Sex Transm Infect. 1999 Jun ;75(3):200.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: