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Curr Opin Neurobiol. 1999 Aug;9(4):410-8.

Molecular mechanisms of vertebrate photoreceptor light adaptation.

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  • 1FM Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, Institute of Neurological Sciences, Stellar-Chance Laboratories, University of Pennsylvania, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104-6069, USA.


An important recent advance in the understanding of vertebrate photoreceptor light adaptation has come from the discovery that as many as eight distinct molecular mechanisms may be involved, and the realization that one of the principal mechanisms is not dependent on calcium. Quantitative analysis of these mechanisms is providing new insights into the nature of rod photoreceptor light adaptation.

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